Darwinian alchemy: Human genes from noncoding DNA.
نویسنده
چکیده
References http://genome.cshlp.org/content/19/10/1693.full.html#ref-list-1 This article cites 21 articles, 15 of which can be accessed free at: Related Content Genome Res. October , 2009 19: 1752-1759 David G. Knowles and Aoife McLysaght Recent de novo origin of human protein-coding genes service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this article sign up in the box at the
منابع مشابه
Expandable DNA Repeat and Human Hereditary Disorders
Background & Aims: Nearly 30 hereditary disorders in humans result from an increase in the number of copies of simple repeats in genomic DNA, including fragile X syndrome, myotonic dystrophy, Huntington’s disease, and Friedreich’s ataxia. One the most frequently occurring types of mutation is trinucleotide repeat expansion. The present study was conducted with the aim of investigating the cause...
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متن کاملRecent de novo origin of human protein-coding genes.
The origin of new genes is extremely important to evolutionary innovation. Most new genes arise from existing genes through duplication or recombination. The origin of new genes from noncoding DNA is extremely rare, and very few eukaryotic examples are known. We present evidence for the de novo origin of at least three human protein-coding genes since the divergence with chimp. Each of these ge...
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Selection against deleterious mutations imposes a mutation load on populations because individuals die or fail to reproduce. In vertebrates, estimates of genomic rates of deleterious mutations in protein-coding genes imply the existence of a substantial mutation load, but many functionally important regions of the genome are thought to reside in noncoding DNA, and the contribution of noncoding ...
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Study Hypothesis Less than 2% of human DNA codes for proteins, whereas the vast majority of DNA in the human genome consists of sequences with unknown function. A substantial portion of the noncoding sequences harbors regulatory motifs important for gene expression. Recent genome-wide association studies (GWAS) suggest that the majority of single nucleotide polymorphisms (SNPs) associated with ...
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عنوان ژورنال:
- Genome research
دوره 19 10 شماره
صفحات -
تاریخ انتشار 2009